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Program
Rejuran
Rejuran Program: Supporting Skin Rejuvenation & Hydration
Table of content
The Rejuran Program is a skin treatment featuring polynucleotides (PN), which are DNA fragments derived from wild salmon. This treatment is designed to support skin revitalization by delivering bio-compatible polynucleotides directly into the skin.
Supports Skin Recovery
The Rejuran Program is designed to support skin revitalization and help improve the appearance of concerns such as wrinkles, scars, large pores, redness, and pigmentation.
Helps Maintain Skin Elasticity and Fine Lines
The Rejuran Program supports the skin’s extracellular matrix (ECM) and hydration, which may contribute to improved skin elasticity and the reduced appearance of fine lines over time.
Supports an Even Skin Tone and Smoother Texture
The Rejuran Program helps balance skin tone and supports overall skin texture, contributing to a more refreshed appearance.
Recognized for Biocompatibility
The Rejuran Program contains highly biocompatible polynucleotides (PN) and has been widely used in aesthetic treatments. Individual responses may vary.
Hydration and Skin Elasticity Support
Program Rejuran helps maintain skin hydration and elasticity, contributing to a more supple and refreshed look.
Program Rejuran is a medical device made from purified polynucleotides (PN).
PN (Polynucleotide)
DNA fragments extracted from wild salmon, managed by the company’s patent technology, DOTTM.
Clear, colorless viscous solution.
Slowly degrades while maintaining uniform structure in tissue.
Designed to be compatible with human skin, with minimal reported side effects.
Supports the skin’s natural reparative process.
Helps maintain skin elasticity and supports the biological condition of the dermis and epidermis.
Balanced Care for Your Skin
The Rejuran Program is designed to support skin revitalization by helping maintain the skin’s natural regenerative process.
Remark
- The Rejuran Program is manufactured in production facilities certified with KGMP (Korea Good Manufacturing Practice), ISO 13485 and etc.
- The Rejuran Program undergoes terminal moist-heat sterilization.
- The Rejuran Program incorporates patented technology for the extraction, purification, and distillation of its active ingredient, polynucleotide (PN) [Patent No. 10-1476381].
Rejuran Program: Product Variations and Uses
A Comprehensive Overview of Rejuran Program’s Formulations
*Individual results may vary depending on individual patient
Pharmaresearch Products. Rejuran: Polynucleotide (PN) Skin Rejuvenation & Regeneration. 2020. Available from: Medical JJ.
Program Rejuran Healer, I , S
Designed for Full Face, Eye Area, and Depressed Scars. Suitable for Individuals Who:
- Seek to support natural skin quality
- Prefer a refreshed and firmer-looking skin appearance
- Look for an overall approach to skin care
- Have fine lines on the face
- Have sensitive or thin skin
- Prefer alternatives to filler program or toxin treatments
- Are exploring skin care options
- Have concerns from prior treatments
- Wish to support skin vitality through non-surgical methods
Program Rejuran HB
Designed to Support Skin Hydration and Rejuvenation
- PN
Contains biocompatible polynucleotides (PN) extracted from wild salmon, which support the skin’s natural renewal process.
- HA
A natural component that supports skin hydration.
- LIDOCAINE
Contains lidocaine, commonly used to support comfort during treatment.
Program Rejuran HB
Designed for Treatment Comfort and Efficiency
*Individual results may vary depending on individual patient
Double Effect in Rejuvenation(PN) and Hydration(HA)
Program Rejuran HB gives both the skin healing strengths of PN and the deep skin hydrating benefits of HA
Improved Patient Comfort
Program Rejuran HB contains lidocaine to enhance treatment comfort and optimize the injection experience
Pharmaresearch Products. Rejuran: Polynucleotide (PN) Skin Rejuvenation & Regeneration. 2020. Available from: Medical JJ.
What are the Benefits of Program Rejuran ?
Program Rejuran is a very potent and advanced skin rejuvenation treatment that it can help turn back the clock with its cellular repair properties and help you achieve youthful, natural healthy skin.
*Individual results may vary depending on individual patient
10 Skin Benefits of the Rejuran Program
Supports Skin Balance, Hydration & Texture Improvement
*Individual results may vary depending on individual patient
Pharmaresearch Products. Rejuran: Polynucleotide (PN) Skin Rejuvenation & Regeneration. 2020. Available from: Medical JJ.
What Can You Expect After the Treatment?
*Individual results may vary depending on individual patient
Pharmaresearch Products. Rejuran: Polynucleotide (PN) Skin Rejuvenation & Regeneration. 2020. Available from: Medical JJ.
Clinical Studies
- Skin Revitalization
Program Rejuran is designed to support fibroblast activity, which may contribute to collagen production. Studies have examined its effects on skin rejuvenation.
*Individual results may vary depending on individual patient
Chang sik Pak et al., A phase 3, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare
the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow’s feet; JKMS 2014;201-209.
- Skin Elasticity Support
Program Rejuran supports skin elasticity with regenerating epidermis and dermis healthier from thinned and damaged skin.
*Individual results may vary depending on individual patient
Chang sik Pak et al., A phase 3, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare
the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow’s feet; JKMS 2014;201-209.
- Skin Normalization
The Rejuran Program supports epidermal and dermal layers, contributing to skin structure. This may help reinforce the skin barrier against external factors associated with premature skin aging
*Individual results may vary depending on individual patient
Seoul national university bundang hospital report.
- Increased Skin Hydration & Elasticity
The Rejuran Program supports skin hydration and elasticity, with observed improvements of 14.69% in hydration and 21.78% in elasticity in a clinical study. Individual results may vary.
*Individual results may vary depending on individual patient
Long chain polynucleotides gel and skin biovitalization. Journal of Plastic Dermatology 2007; 3, 3
Clinical Study - Program Rejuran Healer
Full Face Rejuvenation
- Supports skin hydration
- Reduced wrinkles and sagging skin
- Reduced pigmentation
A total of 4 Program Rejuran treatments in two-week intervals
The pore and skin thickness were markedly improved in 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved in 40s
*Individual results may vary depending on individual patient
Park, K. Y., Seok, J., Rho, N. K., Kim, B. J., & Kim, M. N. (2015). Long-chain polynucleotide filler for skin rejuvenation:
efficacy and complications in five patients. Dermatologic Therapy, 29(1), 37–40.
*Individual results may vary depending on individual patient
Clinical Study - Program Rejuran i
Under-Eye Area Rejuvenation
- Fine lines and wrinkles around eyes
- Appearance of eye bags
- Dark circles and crow's feet
Program Rejuran i treatments were performed every two weeks for a total of three times over 12 weeks.
PN administration has been studied for its role in improving the appearance of crow’s feet and fine wrinkles around eyes. and also improves elasticity around eyes area. It has also been evaluated for its potential to support skin elasticity in the under-eye area.
Before and 6 Months After The Treatment
*Individual results may vary depending on individual patient
Before and 6 Months After The Treatment
*Individual results may vary depending on individual patient
A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial to Compare the Durability, Efficacy and Safety between
Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow’s Feet, In house report, 2014
Clinical Study - Program Rejuran s
Scar Treatment
- Post-operative scars after open total thyroidectomy
The experimental group and control group were randomly assigned to compare the efficacy for 16 weeks.
– Experimental group: fractional laser + Program Rejuran s
– Control group: fractional laser + saline
The Vancouver Scar Scale (VSS), global photographic assessment, and objective scar were assessed using 3D camera at baseline and after surgery.
Adjuvant administration of PN, in combination with conventional fractional laser treatment, has been studied for its potential role in supporting wound healing and improving the appearance of post-operative scars after thyroidectomy. Individual responses may vary.
*Individual results may vary depending on individual patient
Preventive Effect of Polynucleotide on Post-thyroidectomy Scars: A Randomized, Double-Blinded, Controlled Trial Lasers in Surgery and
Medicine (SCI), 2018, 755-762
Antera Skin Analysis
*Individual results may vary depending on individual patient
Preventive Effect of Polynucleotide on Post-thyroidectomy Scars: A Randomized, Double-Blinded, Controlled Trial Lasers in Surgery and
Medicine (SCI), 2018, 755-762
FAQs
Program Rejuran is a skin treatment approach, providing a different approach from filler program or laser treatments. It works by supporting the skin’s natural regenerative process, which may help maintain collagen structure and skin elasticity.
This approach supports skin maintenance with a course of four treatments, typically scheduled 2-3 weeks apart, followed by sessions every six months to help maintain skin health.
While some individuals may experience slight swelling or papules on the treated areas immediately after the procedure, these effects are usually temporary and may subside within 24 hours. Most individuals can resume their daily activities as usual, but responses may vary.
For comprehensive skin care, Program Rejuran is applied to the entire face rather than just the eye area, supporting overall skin appearance and addressing visible signs associated with aging and environmental factors. Treatment suitability varies for each individual.
Program Rejuran contains bio-compatible DNA fragments and is designed to support skin revitalization. It is considered for areas that may not be commonly treated with a hyaluronic acid filler program or toxin.
Not when receiving treatment with Program Rejuran. The main ingredient, PN, is considered to have a dose-dependent effect, allowing the skin to gradually absorb and benefit from the treatment.
– Inject with 27- or 30-gauge needle just beneath the dermis after mixing with the lidocaine.
– Anti-pain medications can be taken before the treatment.
– Forehead, Glabella, Around Eyes: Needle – Midface, Jawline: Cannula
– Around lips: Needle
– This depends on the type of dermal filler program or injectable used.
- In some cases, the REJURAN program may be considered alongside certain dermal filler programs, though immune-related reactions should be assessed by a medical professional.
- If combined, different skin layers may be considered for treatment, based on medical assessment.
– Some practitioners may suggest scheduling the REJURAN program a few weeks before other dermal injectable treatments, depending on individual assessment.
– A medical evaluation is recommended before treatment for individuals who have previously undergone facial injectables.
Preventive Effect of Polynucleotide on Post-thyroidectomy Scars: A Randomized, Double-Blinded, Controlled Trial Lasers in Surgery and
Medicine (SCI), 2018, 755-762
