Profhilo Program: Radiant Skin Hydration & Collagen Boost

In today’s world, well-hydrated, youthful-looking skin can enhance confidence. The Profhilo Program, a collagen booster, works alongside traditional fillers by helping to hydrate the skin and support collagen production. The result? Skin that looks firmer, smoother, and naturally radiant.

In today’s world, well-hydrated, youthful-looking skin can enhance confidence. The Profhilo Program, a collagen booster, works alongside traditional fillers by helping to hydrate the skin and support collagen production. The result? Skin that looks firmer, smoother, and naturally radiant.

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Profhilo Program: A Collagen Booster for Skin Hydration

The Profhilo program is a collagen booster designed to help hydrate the skin, support elasticity, and enhance skin vitality1. Formulated with a hybrid hyaluronic acid complex, it spreads seamlessly beneath the skin, helping to promote collagen and elastin production for improved firmness, smoothness, and long-lasting hydration².

With its ability to enhance fibroblast, keratinocyte, and adipocyte activity, the Profhilo program promotes natural skin remodeling, helping improve skin smoothness and radiance for a refreshed and youthful-looking appearance³.

How NAHYCO Hybrid Technology Powers Profhilo Program

NAHYCO Hybrid Technology supports skin rejuvenation through a patented thermal stabilization process. This method blends high- and low-molecular-weight hyaluronic acid (HA) to enhance hydration, elasticity, and collagen stimulation—all without chemical cross-linking agents. As the core technology of the Profhilo Program, this collagen booster revitalizes the skin, promoting a smoother, more radiant, and refreshed complexion.³

Profhilo Program: The 4-Step Process Behind NAHYCO Hybrid Technology

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Step 1: Molecule Combination

A precise mix of high- (1100-1400 kDa) and low- (80-100 kDa) molecular-weight HA (32 mg each) is combined to ensure optimal skin absorption and effectiveness.³

Step 1: Molecule Combination

A precise mix of high- (1100-1400 kDa) and low- (80-100 kDa) molecular-weight HA (32 mg each) is combined to ensure optimal skin absorption and effectiveness.³

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Step 2: Rising Temperature

This patented thermal process heats the mixture, breaking weak hydrogen bonds that stabilize high-molecular-weight HA.³

Step 2: Rising Temperature

This patented thermal process heats the mixture, breaking weak hydrogen bonds that stabilize high-molecular-weight HA.³

profhilo collagen booster hyaluronic acid hybrid complex lowering temperature hydrogen bond formation high low molecular weight ha skin rejuvenation

Step 3: Lowering Temperature

As the temperature lowers, new hydrogen bonds form between high- and low-molecular-weight HA molecules, stabilizing the hybrid cooperative complexes (HCC).³

Step 3: Lowering Temperature

As the temperature lowers, new hydrogen bonds form between high- and low-molecular-weight HA molecules, stabilizing the hybrid cooperative complexes (HCC).³

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Step 4: Hybrid Complex Formation

The process creates a stabilized hybrid cooperative complex, ensuring biocompatibility, seamless tissue integration, and long-lasting skin hydration.³

Step 4: Hybrid Complex Formation

The process creates a stabilized hybrid cooperative complex, ensuring biocompatibility, seamless tissue integration, and long-lasting skin hydration.³

The Role of NAHYCO Hybrid Technology in the Profhilo Program³

The Profhilo program is free from chemical cross-linkers, ensuring higher biocompatibility.

With 64 mg of hyaluronic acid per 2 mL (1 syringe), the Profhilo program provides a high concentration of hyaluronic acid, supporting skin hydration and balance.

The formulation of the Profhilo Program, a collagen booster, allows it to spread evenly across large areas, supporting balanced skin hydration and enhancing overall skin appearance

The Profhilo program works deep within the skin to support collagen and elastin production, helping to enhance hydration, firmness, and elasticity for a naturally refreshed appearance.

The Profhilo program is not just another Hyaluronic acid injectable—it’s a skin bioremodeling treatment that hydrates and enhances skin from within.

BAP Approach: A Guide to Profhilo Program Injections

The Bio Aesthetic Points (BAP) approach is a structured injection method used in the Profhilo program to optimize injection placement. By utilizing the Profhilo program’s hybrid hyaluronic acid (HA) complex, this technique enhances skin hydration, improving elasticity, radiance, and overall skin quality.²

Originally developed for the face, the BAP approach is now used on the neck, inner arms, and hands, targeting areas prone to dehydration and skin laxity. Its high spreadability ensures even distribution, delivering intense hydration, a healthy glow, and visibly refined pores. As a collagen booster, the Profhilo program naturally rejuvenates the skin.

Key Features of the BAP Approach

This injection method enhances the Profhilo program by:

  • Reduced risks by avoiding major blood vessels and nerve branches. 
  • Enhanced product diffusion in areas prone to volume loss and skin thinning.
  • Deep skin remodeling with minimal discomfort and downtime.5

With small, precise injections, hyaluronic acid spreads naturally, aiming to maintain hydration and support skin elasticity while ensuring a comfortable experience.

Profhilo Program in Action: See the BAP Approach’s Real Results

The Profhilo Program helps support skin hydration and maintain elasticity. As a collagen booster, it enhances skin structure. According to the Profhilo protocol, the recommended injection areas include:

1. Face (Targeting the Malar & Submalar Areas)

Key Benefits:

  • Helps support skin hydration and maintain moisture balance.
  • Smooths fine lines, accordion lines (cheek wrinkles from facial movement & aging), and support skin elasticity.
  • Restores a naturally glowing and balanced complexion​.² ³

Profhilo Program’s Protocol: 

  • 5 BAP injection points per side.²
  • Injected into the superficial subcutaneous layer for even diffusion.

Recommended Treatment Sessions:

  • 2 sessions, 1 month apart.
  • Maintenance twice a year.³

Real Results:

1. Neck

Key Benefits:

  • Support skin hydration and smoothness, reducing fine lines.
  • Maintains moisture balance and supports skin elasticity for a more supple look.
  • Improves skin resilience, ensuring long-lasting hydration​.² ³

Profhilo Program’s Protocol: 

  • 10 BAP injection points.²
  • Targets dehydration and texture irregularities.

Recommended Treatment Sessions:

  • 2 sessions, 1 month apart.
  • Maintenance twice a year​.³

Real Results:

3. Inner Arms

Key Benefits:

  • Improves hydration, elasticity, and skin texture.
  • Softens crepey skin, restoring a smoother, healthier appearance.
  • Enhances collagen production, helping the skin retain moisture.³

Profhilo Program’s Protocol: 

  • 7 injection points per arm, ensuring uniform spread of the product.³
  • Targets dehydrated and thinning skin, improving hydration levels and elasticity​.

Recommended Treatment Sessions:

  • 2 sessions, 3-4 weeks apart.
  • Maintenance 2-3 times per year​.³

Real Results:

4. Hands

Key Benefits:

  • Helps hydrate the skin, reducing dryness and rough texture.
  • Improves softness and elasticity, restoring a youthful look.
  • Enhances moisture retention, keeping hands smooth and radiant​.³

Profhilo Program’s Protocol: 

  • Fanning injection technique.³
  • Targets dehydrated and thinning skin, improving hydration levels and elasticity​.

Recommended Treatment Sessions:

  • 2 sessions, 1 month apart.
  • Maintenance twice a year​.³

Real Results:

Profhilo Program by the Numbers: Hydration & Elasticity Boost

The Core Effect: Hydration Boost

A Clinical study on 15 women using the BAP approach reveals hydration improvements:

  • +20% boost in skin hydration after just 1 session.
  • Moisture retention supports hydration for a healthy glow.

The Bonus Effect: Enhanced Skin Elasticity

  • Significant improvement in skin elasticity observed after 2 sessions.
  • The Profhilo Program is ideal for those seeking deep hydration or addressing early signs of aging.

Is the Profhilo Program Right for You?

Profhilo program is a collagen booster designed to support skin hydration and improve skin texture while helping maintain elasticity—without altering facial contours. If you’re experiencing dullness, dehydration, or early signs of skin laxity, this approach may be suitable for you.

Who Can Benefit?

Beyond Injection: BSL Clinic’s Personalized Profhilo Program

At BSL Clinic, we take a personalized, science-based approach to skin rejuvenation, focusing on precision and natural-looking results.

  • Comprehensive Assessment: Evaluates skin quality, including fine lines, pores, pigmentation, and texture, to generate a detailed skin profile.
  • Tailored Treatment Plans: Data-driven insights help customize the Profhilo Program based on individual skin needs.
  • Progress Tracking: Track progress with before-and-after comparisons for visible, data-backed improvements.
  • Precision Mapping: Strategically placed injection points designed to support collagen production and hydration.
  • Comfort: The BAP method promotes even distribution for balanced, natural-looking results with minimal discomfort.
  • Subtle, Natural Rejuvenation: Supports skin quality without excessive volume or artificial-looking changes.
  • Trained Team: Treatments are provided by licensed doctors and skilled medical assistants.
  • Seamless Patient Experience: From consultation and scheduling to post-treatment care, we ensure a smooth and satisfying journey.
  1. Agolli E, Diffidenti B, Di Zitti N, Massidda E, Patella F, Santerini C, et al. Hybrid cooperative complexes of high and low molecular weight hyaluronans (Profhilo®): review of the literature and presentation of the VisionHA project. Esperienze Dermatol. 2018;20(1):5-14. DOI: 10.23736/S1128-9155.18.00470-3.
  2. IBSA. Profhilo Brochure – Face and Neck. IBSA International; 2024.
  3. IBSA. Profhilo Brochure [Internet]. 2023. Available from: https://drsaber.com.au/wp-content/uploads/2023/10/Profhilo-Brochure-.pdf
  4. Beatini M, et al. The Bio Aesthetic Points (BAP) technique for Profhilo®: A targeted approach to tissue remodeling [Internet]. 2016. Available from: https://profhilo.com.br/wp-content/uploads/2021/10/2016-beatini-bap-1.pdf
  5. Satardinova E. Hybrid cooperative complexes of high and low molecular weight hyaluronans for facial skin rejuvenation: a case series. Esperienze Dermatol. 2019. Available from:  https://consensus.app/papers/hybrid-cooperative-complexes-of-high-and-low-molecular-satardinova/60ab8c3586835b93b0b44dc62e9e5930
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